BA6b9
BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM–PIP2-binding domain with a IC50 value of 8.6 µM (WT SK4). BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the S4–S5 linker. BA6b9 significantly prolongs atrial and atrioventricular effective refractory period (ERP) and reduces atrial fibrillation (AF) induction in rat isolated hearts, which has the potential to be used for the research of arrhythmia .
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- CAS No.: 609335-29-7
- 화학식: C14H19NO2
- 분자량:233.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 8.6 μM (WT SK4 Channel)[1]
In Vitro
BA6b9 (10 μM) strongly inhibits calcium-activated SK4 channels by raising the EC50 for Ca2+ activation from 65 nM to 435 nM [1]. BA6b9 (10 μM) exhibits a reduced heart rate, an increased PR interval, prolongation of atrial and atrioventricular effective refractory period (ERP) , and inhibits carbachol-induced atrial fibrillation (AF) in the Langendorff isolated heart model from adult male Sprague-Dawley rats (200-250 g) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 609335-29-7
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분자량 233.31
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화학식 C14H19NO2
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SMILES
O=C1OC2=C(N1CCCCCCC)C=CC=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BA6b9 Related Classifications
HY-163735 Related Classifications
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