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Cat. No.: HY-146183

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BCL6-IN-9

BCL6-IN-9 (compound 1) is a potent B-cell lymphoma 6 protein (BCL6) inhibitor, with an IC₅₀ of 3.9 nM. BCL6-IN-9 can be used for the research of cancer.

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CAS No.: 2378852-76-5
화학식: C₂₂H₁₈ClF₂N₅O₂
분자량:457.86

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BCL6-IN-9 Chemical Structure

CAS No.: 2378852-76-5

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BCL6-IN-9 (compound 1) is a potent B-cell lymphoma 6 protein (BCL6) inhibitor, with an IC₅₀ of 3.9 nM. BCL6-IN-9 can be used for the research of cancer^[1].

IC₅₀ & Target

IC50: 3.9 nM (B-cell lymphoma 6 protein)^[1]

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	GI₅₀	0.19 μM Compound: 1	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay	[PMID: 35657291]
OCI-Ly1	GI₅₀	0.17 μM Compound: 1	Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay	[PMID: 35657291]
OCI-Ly3	GI₅₀	3.4 μM Compound: 1	Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay	[PMID: 35657291]

Chemical Information

CAS No. 2378852-76-5
분자량 457.86
화학식 C₂₂H₁₈ClF₂N₅O₂
SMILES

N#CC1=C(NC2=CC3=C(N(C)C(C4=C3N[C@@H](C5CC5)C(F)(F)CO4)=O)C=C2)C=CN=C1Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Davis OA, et, al. Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J Med Chem. 2022 Jun 3. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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