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Cat. No.: HY-160129

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Centanamycin

Name: Centanamycin
Brand: MedChemExpress
SKU: HY-160129
Availability: PreOrder

(Synonyms: ML-970; AS-I-145; NSC 716970)

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening.

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CAS No.: 413577-16-9
화학식: C₂₄H₂₄ClN₃O₄
분자량:453.92

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Centanamycin Chemical Structure

CAS No.: 413577-16-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	0.045 μM Compound: 11a	The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50% The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%	[PMID: 15916443]
L1210	IC₅₀	0.18 μM Compound: 11a	The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50% The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%	[PMID: 15916443]
L1210	IC₅₀	55 nM Compound: 6	Cytotoxicity against mouse L1210 cells after 3 days by MTT assay Cytotoxicity against mouse L1210 cells after 3 days by MTT assay	[PMID: 20579889]
P815	IC₅₀	0.068 μM Compound: 11a	The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50% The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%	[PMID: 15916443]
P815	IC₅₀	0.068 μM Compound: 4, CBI-TMI	Cytotoxicity against mouse P815 cells after 3 days Cytotoxicity against mouse P815 cells after 3 days	[PMID: 16919946]

Chemical Information

CAS No. 413577-16-9
분자량 453.92
화학식 C₂₄H₂₄ClN₃O₄
SMILES

O=C(C1=CC2=C(N1)C(OC)=C(OC)C(OC)=C2)NC3=C(CCCl)C4=C(C=CC=C4)C(N)=C3
Synonyms

ML-970; AS-I-145; NSC 716970
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rayburn E, et al. Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent. Cancer Chemother Pharmacol. 2012;69(6):1423-1431. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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