country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P12377

Copy Link Print Information

cTP-AlkF-2

cTP-AlkF-2 is a macrocyclic peptide targeting the ganglioside GT1b receptor and can cross the blood-brain barrier. cTP-AlkF-2 induces caveolae-mediated endocytosis/transcytosis, macropinocytosis-mediated internalization, and energy-dependent active transport. cTP-AlkF-2 can serve as a delivery carrier for the synthesis of PVtCD-cTP-AlkF-2 (HY-188196). cTP-AlkF-2 can be used for research on Alzheimer's disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₀₁H₁₄₁F₁₂N₂₅O₂₆S₂
분자량:2413.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

cTP-AlkF-2 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Lysosomal MetabolismOxidative StressAβ/Tau/α-Synuclein AggregationProtein/Amino Acid MetabolismOthers

Lysosomal Metabolism

cTP-AlkF-2 internalizes into hCMEC/D3 cells via caveolae-mediated endocytosis and macropinocytosis^[1].
cTP-AlkF-2 (4 °C) is internalized in brain microvascular endothelial cells mainly through caveolae-mediated endocytosis and macropinocytosis^[2].

Oxidative Stress

cTP-AlkF-2 (24 h) is stable at pH 7.4 in the absence of H₂O₂ and undergoes nearly complete decaging upon ROS triggering^[1].

Oxidative Stress

Aβ/Tau/α-Synuclein Aggregation

Protein/Amino Acid Metabolism

cTP-AlkF-2 (10 μM) selectively reduces total DAPK1 by 62% in Aβ42-exposed SH-SY5Y neurons while not affecting phosphorylated DAPK1^[1].

Others

cTP-AlkF-2 (4 h) shows 11.6-fold higher uptake in hCMEC/D3 cells than the unconjugated DAPK1-binding peptide and 5.6-fold higher uptake than the linear shuttle peptide TP^[1].
cTP-AlkF-2 exhibits enhanced uptake by SH-SY5Y neurons and penetrates the endothelial layer of hCMEC/D3/SH-SY5Y spheroids, accumulating in the neuronal core^[1].
cTP-AlkF-2 (5 µM; 4 h) shows 7.71-fold higher uptake in PC12 cells than FITC-TP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

분자량 2413.46
화학식 C₁₀₁H₁₄₁F₁₂N₂₅O₂₆S₂
SMILES

O=C1C(CC(N1CCC(OCC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(COC(CCN2C(CC(C2=O)SC[C@H](N)C(N3)=O)=O)=O)F)F)F)F)F)F)=O)=O)SC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3CC4=CNC=N4)=O)CC(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)CCCCN)=O)CC7=CC=C(O)C=C7)=O)CCCNC(N)=N)=O)C(N)=O
Sequence

Cys-His-Leu-Asn-Ile-Leu-Ser-Thr-Leu-Trp-Lys-Tyr-Arg-Cys-NH2 (cyclo with ALKF-2)
Sequence Shortening

CHLNILSTLWKYRC-NH2 (cyclo with ALKF-2)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Peng L, et al. Blood-Brain Barrier-Permeable Macrocyclic Chimeras (BmTACs) for Targeted Protein Degradation in the Aging Brain. J Am Chem Soc. 2026;148(38):41137–41150.

[2]. Peng L, et al. A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain. Angewandte Chemie (International ed. in English). 2026 Jan 16;65(3):e20279.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기