DPPE-PEG2000-TH

DPPE-PEG2000-TH is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserted into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. TH peptide: Targeting/functional ligand-TH peptide (AGYLLGHINLHHLAHL (Aib) HHIL) is a histidine-rich pH-sensitive peptide that protonates and forms an α-helix structure in the acidic tumor microenvironment, mediating pH-dependent cell penetration and endosome escape, while also targeting integrin αvβ3.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.