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Cat. No.: HY-114503A

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(E/Z)-NSAH

Name: (E/Z)-NSAH
Brand: MedChemExpress
SKU: HY-114503A
Price: 89.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(E/Z)-NSAH is an isoform of NSAH (HY-114503), which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC₅₀ of 32 μM and cell-based IC₅₀ of ~250 nM, respectively.

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CAS No.: 54009-54-0
화학식: C₁₈H₁₄N₂O₃
분자량:306.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(E/Z)-NSAH Chemical Structure

CAS No.: 54009-54-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	225 nM Compound: E-3a	Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	0.347 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	1.43 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	1.49 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	1.94 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	300 nM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]

Chemical Information

CAS No. 54009-54-0
분자량 306.32
화학식 C₁₈H₁₄N₂O₃
SMILES

O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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