Fonsartan
Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 153235-15-5
- 화학식: C26H30K2N4O5S2
- 분자량:620.87
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Angiotensin Receptor Isoforms
More
Biological Activity
|
AT1 Receptor |
Fonsartan selectively inhibits AT1 receptors (mainly in the adrenal cortex (IC50 = 1.5 × 10-8 M)) while having a lower affinity for AT2 receptors (mainly in the adrenal medulla (IC50 = 1.4 × 10-6 M))[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:A myocardial infarction (MI) model was induced in male normotensive Wistar rats (weighing 250-280 g) by ligating the left anterior descending coronary artery[1].
-
Dosage:3 mg/kg
-
Administration:S.c., once daily for 6 weeks
-
Result:Administration at 30 min, 3 h, 24 h, and 7 d post-administration all inhibited myocardial hypertrophy.
Administration at 3 h and 24 h post-administration significantly reduced infarct size.
Limited effect on improving left ventricular dilation (LVD, LVC).
Chemical Information
-
CAS No. 153235-15-5
-
분자량 620.87
-
화학식 C26H30K2N4O5S2
-
SMILES
O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(N([K])C(NCCC)=O)=O)C=CC=C3)C=C2)O[K]
-
Synonyms
HR 720
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Xia QG, et al. Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure. Cardiovasc Res. 2001 Jan;49(1):110-7. [Content Brief]
[2]. Jin D, et al. Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo. Jpn J Pharmacol. 1997 Nov;75(3):259-66. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fonsartan Related Classifications
HY-19224 Related Classifications
Powered by Bioz