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United States

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Cat. No.: HY-163832

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FPPS-IN-2

FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC₅₀ value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₂₆O₆
분자량:410.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

FPPS-IN-2 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC₅₀ value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis^[1].

IC₅₀ & Target

IC₅₀: 1.108 µM (HFPPS)^[1]

In Vivo

FPPS-IN-2 (compound 4a) (0.1, 1, 10 mg/kg; p.o.; daily for 8 weeks) shows antiosteoporosis efficacy in ovariectomized rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

200-250 g, Female Wistar rats^[1]
Dosage:

0.1, 1, 10 mg/kg
Administration:

P.o.; daily for 8 weeks
Result:

Increased the osteocalcin level only with the 1, and 10 mg/kg doses, reduced urinary calcium.

Chemical Information

분자량 410.46
화학식 C₂₄H₂₆O₆
SMILES

COC1=CC(/C=C/C(C)=O)=CC=C1OCCOC2=CC=C(/C=C/C(C)=O)C=C2OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Sayed NF, et al. Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates. Eur J Med Chem. 2024 Jul 14;276:116679. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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