ADK - adenosine kinase Gene

Also Known as AK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 132

About ADK

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:74,151,221-74,709,290 (from NCBI)

This gene has 14 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 10.9), thyroid (RPKM 8.6) and 25 other tissues.

Summary

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ADK Products (15)

mRNA	Protein	Name
NM_001369123.1	NP_001356052.1	adenosine kinase isoform e
XM_017015703.3	XP_016871192.1	adenosine kinase isoform X5
XM_017015706.2	XP_016871195.1	adenosine kinase isoform X8
NM_001123.4	NP_001114.2	adenosine kinase isoform a
XM_017015699.2	XP_016871188.1	adenosine kinase isoform X3
NM_001202449.2	NP_001189378.1	adenosine kinase isoform c
NM_001202450.2	NP_001189379.1	adenosine kinase isoform d
XM_017015698.2	XP_016871187.1	adenosine kinase isoform X1
NM_006721.4	NP_006712.2	adenosine kinase isoform b
XM_047424621.1	XP_047280577.1	adenosine kinase isoform X9
XM_017015705.2	XP_016871194.1	adenosine kinase isoform X7
XM_017015704.2	XP_016871193.1	adenosine kinase isoform X6
XM_017015702.2	XP_016871191.1	adenosine kinase isoform X4
XM_047424620.1	XP_047280576.1	adenosine kinase isoform X2
NM_001369124.1	NP_001356053.1	adenosine kinase isoform f

ADK Protein Structure

PfkB

0
100
200
300
362 a.a.

Protein Preferred Names	Protein Names
adenosine kinase	adenosine 5'-phosphotransferase testicular tissue protein Li 14

Recombinant ADK Proteins

Cat. No.	상품명	Accession	Purity
HY-P75529	ADK/Adenosine Kinase Protein, Human (sf9, His-GST)	AAH03568 (M1-H345)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75530	ADK/Adenosine Kinase Protein, Human (HEK293)	AAH03568.1 (M1-H345)	≥ 95%, as determined by reducing SDS-PAGE.

ADK Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82944	ADK Antibody (YA2689)	WB, IHC-P	Human, Mouse, Rat
HY-P82944A	ADK Antibody (YA2689)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Splenic Tuberculosis	Tuberculosis, Splenic
Hypermethioninemia	Hepatic Methionine Adenosyltransferase Deficiency Glycine N-Methyltransferase Deficiency Met S-Adenosylhomocysteine Hydrolase Deficiency Deficiency Of Methionine Adenosyltransferase Gnmt Deficiency Mat Deficiency Methionine Adenosyltransferase Deficiency Methioninemia Deficiency Of Acetyl-Coa Acetyltransferase
Purine-Pyrimidine Metabolic Disorder	Inborn Errors Of Purine-Pyrimidine Metabolism Disorder Of Purine Or Pyrimidine Metabolism
Hypermethioninemia Due To Adenosine Kinase Deficiency	Adk Hypermethioninemia Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency Hypermethioninemia Encephalopathy Due To Adk Deficiency Mrt8 Mental Retardation, Autosomal Recessive 8, Formerly Mrt8, Formerly HMAKD Mental Retardation, Autosomal Recessive 8
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Phase
HY-P2952	Recombinant myokinase, Rabbit muscle		/	Phase 4

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS00505	AK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145654	MRS-4203	Inhibitor	/	Unkown
HY-RS00383	ADK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00384	Adk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00385	Adk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADK	RGD	RGD:2046
Canis familiaris	ADK	VGNC	VGNC:37659
Mus musculus	ADK	MGD	MGI:87930
Macaca mulatta	ADK	VGNC	VGNC:69698
Felis catus	ADK	VGNC	VGNC:59644
Others	ADK	NCBI