IL27 - interleukin 27 Gene

Also Known as p28; IL30; IL-27; IL27A; IL-27A; IL27p28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 246778

About IL27

Cytogenetic location: 16p12.1-p11.2 Genomic coordinates (GRCh38): 16:28,499,362-28,506,834 (from NCBI)

This gene has 2 transcripts (splice variants) and 88 orthologues. Biased expression in liver (RPKM 1.5), appendix (RPKM 0.4) and 6 other tissues.

Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

IL27 Products (1)

mRNA	Protein	Name
NM_145659.3	NP_663634.2	interleukin-27 subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19933857	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	12734330	GOA
involved in regulation of T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	12734330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-27 subunit alpha	IL-27 p28 subunit

IL27 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL27	Q8NEV9	CRLF1	Homo sapiens	O75462	Anti Tag CoIP	19933857
Intra	IL27	Q8NEV9	EBI3	Homo sapiens	Q14213	Anti Tag CoIP	20974977

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL27 Proteins

Cat. No.	상품명	Accession	Purity
HY-P73199	IL-27 Protein, Human (CHO, His)	Q14213/NP_005746.2 (R21-K229)&Q8NEV9/NP_663634.2 (F29-P243)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700122AF	Animal-Free IL-30/IL-27A Protein, Human (His)	Q8NEV9 (F29-P243)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Autoimmune Uveitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	상품명	효과	Purity	Phase
HY-P990024	Casdozokitug	Inhibitor	96.49%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-151508	Diamino lipid DAL4		/	Unkown
HY-RS06746	IL27 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06747	IL27RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08889	MYDGF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174612	Human IL27RA mRNA		/	Unkown
HY-174613	Human IL27 mRNA		/	Unkown
HY-RS17022	Ebi3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17036	Il27 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20169	Il27ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23480	Il27 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26673	Il27ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-P990215	Anti-Mouse IL-27 p28 Antibody (MM27.7B1)	Inhibitor	95.00%	Unkown
HY-P992246	Anti-IL-27RA Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL27	VGNC	VGNC:62909
Rattus norvegicus	IL27	RGD	RGD:1561420
Canis familiaris	IL27	VGNC	VGNC:41976
Mus musculus	IL27	MGD	MGI:2384409
Macaca mulatta	IL27	VGNC	VGNC:99516
Bos taurus	IL27	VGNC	VGNC:30150
Others	IL27	NCBI