TM4SF1 - transmembrane 4 L six family member 1 Gene

Also Known as L6; H-L6; M3S1; TAAL6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4071

About TM4SF1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,369,022-149,377,649 (from NCBI)

This gene has 4 transcripts (splice variants), 116 orthologues and 5 paralogues. Broad expression in gall bladder (RPKM 142.0), lung (RPKM 138.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

TM4SF1 Products (2)

mRNA Protein Name
NM_001410837.1 NP_001397766.1 transmembrane 4 L6 family member 1 isoform 2
NM_014220.3 NP_055035.1 transmembrane 4 L6 family member 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11102519 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
7510285 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM4SF1 Protein Structure

L6_membrane

L6_membrane: L6 membrane protein (1 - 195)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

transmembrane 4 L6 family member 1

  • membrane component, chromosome 3, surface marker 1

TM4SF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TM4SF1 P30408 SDCBP2 Homo sapiens Q9H190
Anti Tag CoIP
11102519
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TM4SF1 Proteins

Cat. No. 상품명 Accession Purity
HY-P700837 TM4SF1 Protein-VLP, Human (HEK293) P30408 (M1-C202) Purity analysis by SDS-PAGE is not available for VLP proteins.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-129359 PDP-Pfp 98.27% Unkown
HY-129372 PDdB-Pfp / Unkown
HY-167960 BrAc-Galactose-Sar-N-Me-alanine-DM1 / Unkown
HY-RS14606 TM4SF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19821 Tm4sf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26317 Tm4sf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-P991187 Anti-TM4SF1 Antibody (AGX-A07) Inhibitor 99.01% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TM4SF1 VGNC VGNC:35903
Macaca mulatta TM4SF1 VGNC VGNC:110328
Rattus norvegicus TM4SF1 RGD RGD:1309652
Canis familiaris TM4SF1 VGNC VGNC:52907
Mus musculus TM4SF1 MGD MGI:104678
Felis catus TM4SF1 VGNC VGNC:66224
Others TM4SF1 NCBI