PRKACB - protein kinase cAMP-activated catalytic subunit beta Gene

Also Known as CAFD2; PKACB; PKA C-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5567

About PRKACB

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:84,078,079-84,238,498 (from NCBI)

This gene has 18 transcripts (splice variants), 302 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 61.5), colon (RPKM 21.8) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

PRKACB Products (30)

mRNA	Protein	Name
NM_001242857.3	NP_001229786.1	cAMP-dependent protein kinase catalytic subunit beta isoform 4
NM_001242858.3	NP_001229787.1	cAMP-dependent protein kinase catalytic subunit beta isoform 5
NM_001242859.3	NP_001229788.1	cAMP-dependent protein kinase catalytic subunit beta isoform 6
NM_001242860.3	NP_001229789.1	cAMP-dependent protein kinase catalytic subunit beta isoform 7
NM_001242861.3	NP_001229790.1	cAMP-dependent protein kinase catalytic subunit beta isoform 8
NM_001242862.3	NP_001229791.1	cAMP-dependent protein kinase catalytic subunit beta isoform 9
NM_001300915.2	NP_001287844.1	cAMP-dependent protein kinase catalytic subunit beta isoform 10
NM_001300916.2	NP_001287845.1	cAMP-dependent protein kinase catalytic subunit beta isoform 11
NM_001300917.2	NP_001287846.1	cAMP-dependent protein kinase catalytic subunit beta isoform 12
NM_001375560.1	NP_001362489.1	cAMP-dependent protein kinase catalytic subunit beta isoform 13
NM_001375561.1	NP_001362490.1	cAMP-dependent protein kinase catalytic subunit beta isoform 14
NM_001375562.1	NP_001362491.1	cAMP-dependent protein kinase catalytic subunit beta isoform 15
NM_001375563.1	NP_001362492.1	cAMP-dependent protein kinase catalytic subunit beta isoform 16
NM_001375564.1	NP_001362493.1	cAMP-dependent protein kinase catalytic subunit beta isoform 17
NM_001375565.1	NP_001362494.1	cAMP-dependent protein kinase catalytic subunit beta isoform 18
NM_001375569.1	NP_001362498.1	cAMP-dependent protein kinase catalytic subunit beta isoform 20
NM_001375571.1	NP_001362500.1	cAMP-dependent protein kinase catalytic subunit beta isoform 21
NM_001375572.1	NP_001362501.1	cAMP-dependent protein kinase catalytic subunit beta isoform 22
NM_001375573.1	NP_001362502.1	cAMP-dependent protein kinase catalytic subunit beta isoform 23
NM_001375574.1	NP_001362503.1	cAMP-dependent protein kinase catalytic subunit beta isoform 26
NM_001375575.1	NP_001362504.1	cAMP-dependent protein kinase catalytic subunit beta isoform 24
NM_001375576.1	NP_001362505.1	cAMP-dependent protein kinase catalytic subunit beta isoform 25
NM_001375577.1	NP_001362506.1	cAMP-dependent protein kinase catalytic subunit beta isoform 27
NM_001375578.1	NP_001362507.1	cAMP-dependent protein kinase catalytic subunit beta isoform 28
NM_001375579.1	NP_001362508.1	cAMP-dependent protein kinase catalytic subunit beta isforom 29
NM_001375580.1	NP_001362509.1	cAMP-dependent protein kinase catalytic subunit beta isoform 30
NM_001375581.1	NP_001362510.1	cAMP-dependent protein kinase catalytic subunit beta isoform 19
NM_002731.4	NP_002722.1	cAMP-dependent protein kinase catalytic subunit beta isoform 2
NM_182948.4	NP_891993.1	cAMP-dependent protein kinase catalytic subunit beta isoform 1
NM_207578.3	NP_997461.1	cAMP-dependent protein kinase catalytic subunit beta isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12420224	GOA
enables cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	12420224	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12420224	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21880142	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	21423175	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	31112131	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12420224	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKACB Protein Structure

Pkinase

0
100
200
300
351 a.a.

Protein Preferred Names	Protein Names
cAMP-dependent protein kinase catalytic subunit beta	protein kinase A catalytic subunit beta

PRKACB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKACB	P22694	PKIA	Homo sapiens	P61925	Validated Y2H	32296183
Intra	PRKACB	P22694	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	PRKACB	P22694	HSP90AB1	Homo sapiens	P08238	TAP	23455922
Intra	PRKACB	P22694	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	PRKACB	P22694	AVPI1	Homo sapiens	Q5T686	Y2H Prey Pooling	32296183
Intra	PRKACB	P22694	AVPI1	Homo sapiens	Q5T686	Validated Y2H	32296183
Intra	PRKACB	P22694	AVPI1	Homo sapiens	Q5T686	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKACB Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P810911	PKA C beta Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cardioacrofacial Dysplasia 2	CAFD2
Breast Ductal Adenoma
Breast Adenoma	Ademoma - Breast
Atrioventricular Septal Defect	AVSD Atrioventricular Canal Defect Avcd Endocardial Cushion Defect Ecd Avc Defect Atrioventricular Septal Defect, Susceptibility To, 1 Atrioventricular Septal Defect 1 Endocardial Cushion Defects Septal Defect, Atrioventricular Atrioventricular Defect With Atrial Shunting Only Incomplete Atrioventricular Septal Defect With Isolated Atrial Component Incomplete Atrioventricular Canal Defect With Isolated Atrial Component Primum Atrial Septal Defect Partial Atrioventricular Canal Defect With Isolated Atrial Component Partial Atrioventricular Septal Defect, Ostium Primum Type Ostium Primum Atrial Septal Defect Partial Atrioventricular Canal Defect Partial Atrioventricular Septal Defect Atrial Septum Primum Defect Atrioventricular Canal Defect With Isolated Ventricular Component Atrioventricular Canal Defect With Isolated Ventricular Communication Atrioventricular Septal Defect With Isolated Ventricular Component Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect Intermediate Atrioventricular Canal Defect Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices Intermediate Atrioventricular Septal Defect Transitional Atrioventricular Canal Defect Transitional Atrioventricular Septal Defect Complete Atrioventricular Canal With Atrial And Ventricular Components Complete Atrioventricular Canal Defect Complete Atrioventricular Septal Defect
Melanotic Neurilemmoma	Melanotic Schwannoma Pigmented Neurilemmoma Pigmented Schwannoma
Cervical Non-Keratinizing Squamous Cell Carcinoma
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Cervical Keratinizing Squamous Cell Carcinoma
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Thrombophilia Due To Hrg Deficiency	Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency Hereditary Thrombophilia Due To Congenital Hrg Deficiency Thph11
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Mccune-Albright Syndrome	Mass Syndrome Polyostotic Fibrous Dysplasia MAS Fibrous Dysplasia Of Bone Albright Syndrome Mass Phenotype Overlap Connective Tissue Disease Mccune Albright Syndrome Osteitis Fibrosa Disseminata OCTD Albright'S Disease Pfd Pofd Albright'S Syndrome Mccune-Albright Syndrome, Somatic, Mosaic Albright'S Disease Of Bone Albright'S Syndrome With Precocious Puberty Albright-Mccune-Sternberg Syndrome Albright-Sternberg Syndrome Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty Gonadotropin-Independent Female-Limited Sexual Precocity Fibrous Dysplasia Polyostotic Fibrous Dysplasia, Polyostotic
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Brachydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS11107	PRKACB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRKACB	VGNC	VGNC:33321
Canis familiaris	PRKACB	VGNC	VGNC:44971
Rattus norvegicus	PRKACB	RGD	RGD:1310574
Mus musculus	PRKACB	MGD	MGI:97594
Felis catus	PRKACB	VGNC	VGNC:80322
Macaca mulatta	PRKACB	VGNC	VGNC:97808
Others	PRKACB	NCBI