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RAB2A - RAB2A, member RAS oncogene family Gene

Also Known as LHX; RAB2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5862

About RAB2A

Cytogenetic location: 8q12.1-q12.2 Genomic coordinates (GRCh38): 8:60,516,910-60,623,644 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 44.0), thyroid (RPKM 43.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RAB2A Products (2)

mRNA	Protein	Name
NM_001242644.1	NP_001229573.1	ras-related protein Rab-2A isoform b
NM_002865.3	NP_002856.1	ras-related protein Rab-2A isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16034420	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	16034420	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16034420	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17684057	GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	28483915	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB2A Protein Structure

Ras

0
100
200
212 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-2A	RAB2, member RAS oncogene family

RAB2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB2A	P61019	ICA1	Homo sapiens	Q05084	Y2H Array	25416956
Intra	RAB2A	P61019	ICA1	Homo sapiens	Q05084	Y2H Array	29892012
Intra	RAB2A	P61019	ICA1	Homo sapiens	Q05084	Y2H Prey Pooling	25416956
Intra	RAB2A	P61019	FAM114A2	Homo sapiens	Q9NRY5	Validated Y2H	32296183
Intra	RAB2A	P61019	FAM114A2	Homo sapiens	Q9NRY5	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	FAM114A2	Homo sapiens	Q9NRY5	Y2H Array	32296183
Intra	RAB2A	P61019	FRMD1	Homo sapiens	Q8N878	Validated Y2H	32296183
Intra	RAB2A	P61019	TBC1D25	Homo sapiens	Q3MII6	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	TBC1D25	Homo sapiens	Q3MII6	Y2H Array	32296183
Intra	RAB2A	P61019	TBC1D25	Homo sapiens	Q3MII6	Validated Y2H	32296183
Intra	RAB2A	P61019	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	RAB2A	P61019	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	RAB2A	P61019	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	PMAIP1	Homo sapiens	Q13794-2	Validated Y2H	32296183
Intra	RAB2A	P61019	GARIN1A	Homo sapiens	Q6NXP2-2	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	GARIN1A	Homo sapiens	Q6NXP2-2	Y2H Array	32296183
Intra	RAB2A	P61019	GARIN1A	Homo sapiens	Q6NXP2-2	Validated Y2H	32296183
Intra	RAB2A	P61019	GARIN4	Homo sapiens	Q8IYT1	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	GARIN4	Homo sapiens	Q8IYT1	Validated Y2H	32296183
Intra	RAB2A	P61019	GARIN4	Homo sapiens	Q8IYT1	Y2H Array	32296183
Intra	RAB2A	P61019	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	RAB2A	P61019	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	RAB2A	P61019	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	31515488
Intra	RAB2A	P61019	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Y2H Array	31515488
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Validated Y2H	25416956
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Y2H Prey Pooling	25416956
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Validated Y2H	32296183
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Y2H Array	25416956
Intra	RAB2A	P61019	FAM114A1	Homo sapiens	Q8IWE2	Y2H Array	32296183
Intra	RAB2A	P61019	TRIM7	Homo sapiens	Q9C029	Validated Y2H	32296183
Intra	RAB2A	P61019	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
Intra	RAB2A	P61019	CFL2	Homo sapiens	Q9Y281	Validated Y2H	32296183
Intra	RAB2A	P61019	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	RAB2A	P61019	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	RAB2A	P61019	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RAB2A	P61019	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	RAB2A	P61019	TMEM70	Homo sapiens	Q9BUB7	Validated Y2H	32296183
Intra	RAB2A	P61019	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	25416956
Intra	RAB2A	P61019	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	32296183
Intra	RAB2A	P61019	STAMBPL1	Homo sapiens	Q96FJ0	Validated Y2H	32296183
Intra	RAB2A	P61019	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Array	32296183
Intra	RAB2A	P61019	STAMBPL1	Homo sapiens	Q96FJ0	Y2H	21516116
Intra	RAB2A	P61019	HES6	Homo sapiens	Q96HZ4	Validated Y2H	32296183
Intra	RAB2A	P61019	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	32296183
Intra	RAB2A	P61019	GARIN6	Homo sapiens	Q8NEG0	Y2H Array	32296183
Intra	RAB2A	P61019	GARIN6	Homo sapiens	Q8NEG0	Y2H Pooling	16189514
Intra	RAB2A	P61019	GARIN6	Homo sapiens	Q8NEG0	Y2H Prey Pooling	25416956
Intra	RAB2A	P61019	GARIN6	Homo sapiens	Q8NEG0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB2A Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P85463	Rab2 Antibody (YA5155)	WB, ICC/IF	Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish
HY-P85526	Rab2 Antibody (YA5218)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Lipoblastoma
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Chronic Salpingo-Oophoritis	Chronic Salpingitis And Oophoritis Chronic Salpingitis/Oophoritis
Warburg Micro Syndrome 3	WARBM3 Micro Syndrome 3
Warburg Micro Syndrome 2	WARBM2 Micro Syndrome 2
Smith-Mccort Dysplasia 1	Smith-Mccort Dysplasia SMC1 Smc Smith Mccort Dysplasia Smith-Mccort Dwarfism
Warburg Micro Syndrome 4	WARBM4 Micro Syndrome 4
Salpingo-Oophoritis	Tubo-Ovarian Inflammatory Disease Salpingitis/Oophoritis Suppurative Salpingo Oophoritis Tubo-Ovarian Inflammation Tubo-Ovarian Inflammatory Disorder Purulent Salpingo Oophoritis Septic Salpingo Oophoritis Salpingo-Ovaritis Inflammation Oviduct Ruptured Salpingo Oophoritis Pyosalpinx Rupture
Dyggve-Melchior-Clausen Disease	Dyggve-Melchior-Clausen Syndrome DMC Dmc Disease Pseudo-Morquio Disease Type I Dmc Syndrome
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-124306	ML-099	Activator	99.75%	Unkown
HY-RS11541	RAB2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18838	Rab2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25330	Rab2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAB2A	VGNC	VGNC:33637
Canis familiaris	RAB2A	VGNC	VGNC:45271
Macaca mulatta	RAB2A	VGNC	VGNC:81529
Felis catus	RAB2A	VGNC	VGNC:97587
Mus musculus	RAB2A	MGD	MGI:1928750
Rattus norvegicus	RAB2A	RGD	RGD:68323
Others	RAB2A	NCBI