Aplf - aprataxin and PNKP like factor Gene

Also Known as 2010301N04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72103

Summary

Predicted to enable DNA-(apurinic or apyrimidinic site) Endonuclease activity; nuclease activity; and nucleotide binding activity. Acts upstream of or within double-strand break repair and regulation of isotype switching. Predicted to be located in nucleoplasm. Predicted to be active in nucleus and site of double-strand break. Orthologous to human APLF (aprataxin and PNKP like factor). [provided by Alliance of Genome Resources, Apr 2022]

Aplf Products (3)

mRNA Protein Name
NM_001170489.1 NP_001163960.1 aprataxin and PNK-like factor isoform 1
NM_001372332.1 NP_001359261.1 aprataxin and PNK-like factor isoform 3
NM_024251.4 NP_077213.2 aprataxin and PNK-like factor isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
21211721 MGI
involved in embryo implantation IMP
IMP: Inferred from mutant phenotype
33277378 MGI
involved in regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
33277378 MGI
acts upstream of or within regulation of isotype switching IMP
IMP: Inferred from mutant phenotype
21211721 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
33277378 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
33277378 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aprataxin and PNK-like factor

  • apurinic-apyrimidinic endonuclease APLF

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS00821 APLF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22105 Aplf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28626 Aplf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aplf NCBI NCBI:200558