Glyphosate-d2-1
Glyphosate-d2-1 is the deuterium labeled Glyphosate. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants.
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- CAS No.: 2734001-36-4
- 화학식: C3H6D2NO5P
- 분자량:171.09
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2734001-36-4
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Unlabeled Cas 1071-83-6
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Appearance Solid
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분자량 171.09
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화학식 C3H6D2NO5P
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Color White to off-white
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SMILES
OC(C([2H])([2H])NCP(O)(O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
H2O : 13.89 mg/mL (81.19 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Greim H, et al. Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45(3):185-208. [Content Brief]
[3]. Zhang JW, et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec237:124435. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.8449 mL | 29.2244 mL | 58.4488 mL | 146.1219 mL |
| 5 mM | 1.1690 mL | 5.8449 mL | 11.6898 mL | 29.2244 mL | |
| 10 mM | 0.5845 mL | 2.9224 mL | 5.8449 mL | 14.6122 mL | |
| 15 mM | 0.3897 mL | 1.9483 mL | 3.8966 mL | 9.7415 mL | |
| 20 mM | 0.2922 mL | 1.4612 mL | 2.9224 mL | 7.3061 mL | |
| 25 mM | 0.2338 mL | 1.1690 mL | 2.3380 mL | 5.8449 mL | |
| 30 mM | 0.1948 mL | 0.9741 mL | 1.9483 mL | 4.8707 mL | |
| 40 mM | 0.1461 mL | 0.7306 mL | 1.4612 mL | 3.6530 mL | |
| 50 mM | 0.1169 mL | 0.5845 mL | 1.1690 mL | 2.9224 mL | |
| 60 mM | 0.0974 mL | 0.4871 mL | 0.9741 mL | 2.4354 mL | |
| 80 mM | 0.0731 mL | 0.3653 mL | 0.7306 mL | 1.8265 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Glyphosate-d2-1 Related Classifications
HY-B0863S2 Related Classifications
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