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Cat. No.: HY-111161

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GSK575594A

GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (E_max increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies.

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CAS No.: 909418-68-4
화학식: C₂₄H₂₃F₂N₃O₃S
분자량:471.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GSK575594A Chemical Structure

CAS No.: 909418-68-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	10 μM Compound: GSK575594A	Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay	[PMID: 26575458]

Chemical Information

CAS No. 909418-68-4
분자량 471.52
화학식 C₂₄H₂₃F₂N₃O₃S
SMILES

O=C(N1CCN(C2=CC=C(N)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3C4=CC=C(F)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Stevanovic S, et al. Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach. Mol Biochem Parasitol. 2021 Mar;242:111350. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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GSK575594A

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All Parasite Isoforms

Biological Activity

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GSK575594A Related Classifications

HY-111161 Related Classifications