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Cat. No.: HY-13031

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GW 841819X

Name: GW 841819X
Brand: MedChemExpress
SKU: HY-13031
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

GW 841819X is a benzodiazepine inhibitor of bromodomains of the BET family (BRD2, BRD3, BRD4) that inhibits the binding of Diazepam to central GABA receptors. GW 841819X can be used in the research of BET bromodomain-related diseases, such as cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 146135-18-4
화학식: C₂₅H₂₁N₅O₂
분자량:423.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (288 KB)

GW 841819X Chemical Structure

CAS No.: 146135-18-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
순도&문서
References
Calculators
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Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

apoA1

BRD2

BRD3

BRD4

IL-6

All Epigenetic Reader Domain Isoforms :

All Interleukin Related Isoforms :

All Apolipoprotein Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	440 nM Compound: 1, GW841819X	Induction of human ApoA1 gene expression in stably transfected human HepG2 cells coexpressing luciferase reporter gene after 18 hrs by luminescence assay Induction of human ApoA1 gene expression in stably transfected human HepG2 cells coexpressing luciferase reporter gene after 18 hrs by luminescence assay	[PMID: 21568322]

In Vitro

GW 841819X (compound 7) inhibits purified BRD2, BRD3, and BRD4 bromodomain proteins in fluorescence polarization binding assays, with pIC₅₀ values of 5.9, 6.2, and 6.3, respectively^[1].
GW 841819X induces ApoA1 reporter gene activity in stable human HepG2 hepatocytes, with an EC₁₇₀ of 0.22 μM^[1].
GW 841819X inhibits lipopolysaccharide-induced IL-6 production in human peripheral blood mononuclear cells (pIC₅₀ = 6.8), and suppresses the binding of benzodiazepines to central GABA receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146135-18-4
분자량 423.47
화학식 C₂₅H₂₁N₅O₂
SMILES

CC1=NN=C2N1C3=CC=CC=C3C(C4=CC=CC=C4)=NC2NC(OCC5=CC=CC=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Pharmacol Res

Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders. [Abstract]

2026 Jan 16:108103. PMID: 41548771

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mirguet O, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. Journal of medicinal chemistry. 2013 Oct 10;56(19):7501-15. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

GW 841819X

1 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
순도&문서
References

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GW 841819X

Publications Citing Use of MedChemExpress (MCE) GW 841819X

All Epigenetic Reader Domain Isoforms

All Interleukin Related Isoforms

All Apolipoprotein Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

Calculators

Help & FAQs

GW 841819X Related Classifications

HY-13031 Related Classifications

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