IND8
IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease.
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- CAS No.: 1778682-59-9
- 화학식: C17H19N5
- 분자량:293.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
IND8 potently binds to and activates α7-nAChRs in cells expressing LGIC receptors, with a Kd of 0.12 μM and an EC50 of 0.03 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
IND8 (10-25 μmol/kg; intraperitoneal injection; single administration) improves cognitive function in mice with delayed-induced natural memory decline[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 6-weeks of age, scopolamine-induced amnesia)[1]
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Dosage:5 μmol/kg (1.5 mg/kg); 10 μmol/kg (2.9 mg/kg); 25 μmol/kg (7.3 mg/kg); 50 μmol/kg (14.7 mg/kg)
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Administration:i.p.; single dose
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Result:Significantly reversed scopolamine-induced cognitive deficit, with percentage of unfamiliar arm exploration significantly higher than the scopolamine-treated group.
Increased discrimination index (DI) at 10 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group, and exploration time of the novel object was significantly longer than the familiar object.
Increased time spent in the target quadrant at 25 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group.
Chemical Information
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CAS No. 1778682-59-9
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분자량 293.37
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화학식 C17H19N5
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SMILES
N1(C2CN3CCC2CC3)N=NC(C4=CC5=C(NC=C5)C=C4)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IND8 Related Classifications
HY-116488 Related Classifications
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