country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181764

Copy Link Print Information

LZL50

LZL50 is an orally effective human caseinolytic protease P (hClpP) activator with an EC₅₀ of 0.29 μM. LZL50 activates hClpP, a serine protease that mediates mitochondrial quality control by degrading damaged or misfolded mitochondrial proteins. LZL50 exhibits antitumor activity in a breast cancer xenograft mouse model. LZL50 can be used in research related to breast cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₁H₃₃F₄N₃O₂
분자량:555.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

LZL50 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

LZL50 (5 nM-30 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC₅₀ of 0.30 ± 0.04 μM after 72 h of treatment^[1].
LZL50 (1.0 μM; up to 120 min) has moderate metabolic stability in human liver microsomes, with a CL_int of 46.2 mL/min/kg and a T_1/2 of 39 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-t	AUC_0-∞	T_1/2
Rat^[1]	15 mg/kg	p.o.	1939.24 ng/mL	1.12 h	18403.92 ng·h/mL	19010.67 ng·h/mL	4.37 h

In Vivo

LZL50 (5-20 mg/kg; p.o.; daily; 15 days) demonstrates potent dose-dependent in vivo antitumor activity in MDA-MB-231 xenografted mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude (female, 5 weeks old)^[1]
Dosage:

5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:

p.o.; daily; 15 days
Result:

Nearly completely suppressed tumor growth at 20 mg/kg.
Showed no significant body weight loss in any treatment group during the 15-day treatment period.

Chemical Information

분자량 555.61
화학식 C₃₁H₃₃F₄N₃O₂
SMILES

O=C1N([C@H](CC2=CC=C(C=C21)CC3=CC=C(C=C3)F)COCCN4CCNCC4)CC5=CC=C(C=C5)C(F)(F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Z, et al. Discovery of Activators of Human Caseinolytic Protease P with a Benzolactam Scaffold. J Med Chem. 2026;69(5):6014-6037. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기