PF-07257876
PF-07257876 is a CD47/PD‑L1 bispecific antibody that preferentially targets tumor cells through high PD-L1 affinity and weak CD47 affinity. PF‑07257876 simultaneously blocks the CD47‑SIRPα innate immune checkpoint and the PD‑L1/PD‑1 adaptive immune checkpoint, activates dendritic cells and macrophages, enhances CD8+ T cell infiltration within the tumor microenvironment, and synergistically mobilizes innate and adaptive immunity to exert antitumor effects. PF-07257876 can be used in research on CD47/PD‑L1-related cancers, such as ovarian cancer and non-small cell lung cancer.
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Species Reactivity
Human
In Vitro
PF-07257876 exhibits high affinity for PD-L1 and weaker affinity for CD47, thereby achieving tumor-biased targeting and reducing off-target binding to red blood cells[1][2].
PF‑07257876 can dually inhibit the CD47‑SIRPα and PD‑L1‑PD‑1 immune checkpoint axes, activate dendritic cells and macrophages, enhance CD8+ T cell infiltration in the tumor microenvironment, and generate an innate‑adaptive combined antitumor immune response[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Target
CD47 & PDL1
Conjugated
Unconjugated
신청
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[PF- 07257876]
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-07257876 Related Classifications
HY-P992553 Related Classifications
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