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Cat. No.: HY-W683866

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Piroheptine

Piroheptine is a muscarinic acetylcholine receptor (mAChR) antagonist and dopamine reuptake inhibitor. Piroheptine blocks the high-affinity dopamine transport system, prevents MPP⁺ uptake into dopaminergic neurons, and exerts anticholinergic activity. Piroheptine completely prevents MPTP (HY-W114750)-induced loss of striatal dopamine and DOPAC, and increases striatal dopamine levels. Piroheptine can be used in studies related to Parkinson's disease.

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CAS No.: 16378-21-5
화학식: C₂₂H₂₅N
분자량:303.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Piroheptine Chemical Structure

CAS No.: 16378-21-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All mAChR Isoforms :

In Vivo

Piroheptine (20 mg/kg; i.p.; single dose) completely prevents MPTP-induced striatal dopamine and DOPAC depletion in male C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8-week-old, 20-30 g, Parkinsonism induced via 4 intraperitoneal injections of 10 mg/kg MPTP at 1-hour intervals)^[1]
Dosage:

20 mg/kg
Administration:

i.p.; 30 minutes before each of 4 MPTP injections (1 hour apart); single treatment (piroheptine-alone group)
Result:

Completely prevented MPTP-induced striatal dopamine loss, resulting in levels of 9.5 μg/g wet tissue.
Completely prevented MPTP-induced striatal DOPAC loss, resulting in levels of 0.8 μg/g wet tissue.
Increased striatal dopamine content to 10.2 μg/g wet tissue (approximately 10% higher than saline controls) when administered alone.

Chemical Information

CAS No. 16378-21-5
분자량 303.45
화학식 C₂₂H₂₅N
SMILES

C=1C=CC2=C(C1)C(C=3C=CC=CC3CC2)=C4CCN(CC)C4C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Saitoh T, et al. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. Journal of the neurological sciences. 1988 Feb;83(2-3):161-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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