TLK
Tousled-like kinases TLK1 and TLK2 were named after the Arabidopsis tousled mutant, which shows disrupted floral and leaf development. Both are nuclear serine/threonine kinases with an extended C-terminal region, and their best-characterized substrates are the histone chaperones ASF1A and ASF1B plus the DNA damage regulator Rad9, linking them to chromatin assembly during S phase, DNA replication and checkpoint control. TLK activity peaks in S phase and is shut down by Chk1- and Chk2-mediated phosphorylation after genotoxic stress, transiently halting chromatin duplication. TLK1 and TLK2 also support homologous recombination and spermatogenesis, and TLK1 splice variants have been described in tumors.
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TLK Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
