SW208108
SW208108 is a prodrug of dMe-SW208108, a CYP4F11-activated SCD inhibitor, with an IC50 value of 9 nM. SW208108 undergoes demethylation by CYP4F11 to form the active metabolite dMe-SW208108, thereby inhibiting enzyme function. SW208108 depletes unsaturated fatty acids, induces cytotoxicity in non-small cell lung cancer (NSCLC) cells expressing CYP4F11, and does not affect SCD activity in mouse sebocytes. SW208108 can be used in studies related to NSCLC.
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- CAS No.: 1673557-43-1
- 화학식: C27H24N2O5
- 분자량:456.50
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
SW208108 selectively reduces the viability of four NSCLC cell lines (H2122, H460, HCC44, HCC4017) with an IC50 of 0.014-0.031 μM; it exhibits moderate toxicity against H2073 cells, but shows no toxicity against another seven NSCLC cell lines[1].
SW208108 is selectively metabolized to dMe-SW208108 in H2122 non-small cell lung cancer cells, whereas it remains unmetabolized in H1155 non-small cell lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1673557-43-1
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분자량 456.50
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화학식 C27H24N2O5
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SMILES
O=C(NC1=CC=C(C=C1)C(=O)C2=CC=C(OCC#C)C=C2)C(=O)NCCC3=CC=C(OC)C=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SW208108 Related Classifications
HY-114606 Related Classifications
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