WAY-267464
Based on 2 publication(s) in Google Scholar
WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.12%
- CAS No.: 847375-16-0
- 화학식: C32H35N7O4
- 분자량:581.66
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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![[Asp5]-Oxytocin](https://file.medchemexpress.com/product_pic/hy-p3217.gif)
HY-P3217
[Asp5]-OxytocinNeurohypophyseal Hormone Analogue
Publications Citing Use of MedChemExpress (MCE) WAY-267464
More
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
420 nM
Compound: 1; WAY-267,464
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Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
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[PMID: 26741855] |
| HEK293 | IC50 |
613 nM
Compound: 1; WAY-267,464
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Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
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[PMID: 26741855] |
| HEK293 | EC50 |
>10000 nM
Compound: 1; WAY-267,464
|
Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
|
[PMID: 26741855] |
| HEK293 | IC50 |
>10000 nM
Compound: 1; WAY-267,464
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Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
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[PMID: 26741855] |
In Vivo
WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)[1]
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Dosage:1, 10, 30, and 100 mg/kg
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Administration:Intraperitoneal; 1, 10, 30, and 100 mg/kg
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Result:Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats.
Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.
Chemical Information
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CAS No. 847375-16-0
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Appearance Solid
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분자량 581.66
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화학식 C32H35N7O4
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Color White to off-white
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SMILES
O=C(N1CCN(CC2=CC(O)=CC(O)=C2)CC1)NCC3=CC=C(C(N4CC5=C(N(C)N=C5)NC6=CC=CC=C46)=O)C=C3C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
Parishin A alleviates insomnia by regulating hypothalamic-pituitary-adrenal axis homeostasis and directly targeting orexin receptor OX2. [Abstract]2025 Jul 5:998:177498. PMID: 40064224 -
Sci Rep
2024 Oct 13;14(1):23935. PMID: 39397061
용액&용해도
In Vitro:
DMSO : 50 mg/mL (85.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7192 mL | 8.5961 mL | 17.1922 mL | 42.9804 mL |
| 5 mM | 0.3438 mL | 1.7192 mL | 3.4384 mL | 8.5961 mL | |
| 10 mM | 0.1719 mL | 0.8596 mL | 1.7192 mL | 4.2980 mL | |
| 15 mM | 0.1146 mL | 0.5731 mL | 1.1461 mL | 2.8654 mL | |
| 20 mM | 0.0860 mL | 0.4298 mL | 0.8596 mL | 2.1490 mL | |
| 25 mM | 0.0688 mL | 0.3438 mL | 0.6877 mL | 1.7192 mL | |
| 30 mM | 0.0573 mL | 0.2865 mL | 0.5731 mL | 1.4327 mL | |
| 40 mM | 0.0430 mL | 0.2149 mL | 0.4298 mL | 1.0745 mL | |
| 50 mM | 0.0344 mL | 0.1719 mL | 0.3438 mL | 0.8596 mL | |
| 60 mM | 0.0287 mL | 0.1433 mL | 0.2865 mL | 0.7163 mL | |
| 80 mM | 0.0215 mL | 0.1075 mL | 0.2149 mL | 0.5373 mL |
WAY-267464 Related Classifications
HY-15522 Related Classifications
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