YSK 05
Based on 1 Customer Validation
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo.
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- Purity: 98.68%
- CAS No.: 1318793-78-0
- 화학식: C42H77NO2
- 분자량:628.07
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
YSK 05 facilitates the endosomal escape of the MEND and thereby enhances the efficacy of siRNA delivery into cytosol and gene silencing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1318793-78-0
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Appearance Liquid (Density: 0.91±0.1 g/cm3)
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분자량 628.07
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화학식 C42H77NO2
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Color Colorless to light yellow
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SMILES
CN1CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)(OCCCCCCCC/C=C\C/C=C\CCCCC)CC1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (159.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5922 mL | 7.9609 mL | 15.9218 mL | 39.8045 mL |
| 5 mM | 0.3184 mL | 1.5922 mL | 3.1844 mL | 7.9609 mL | |
| 10 mM | 0.1592 mL | 0.7961 mL | 1.5922 mL | 3.9804 mL | |
| 15 mM | 0.1061 mL | 0.5307 mL | 1.0615 mL | 2.6536 mL | |
| 20 mM | 0.0796 mL | 0.3980 mL | 0.7961 mL | 1.9902 mL | |
| 25 mM | 0.0637 mL | 0.3184 mL | 0.6369 mL | 1.5922 mL | |
| 30 mM | 0.0531 mL | 0.2654 mL | 0.5307 mL | 1.3268 mL | |
| 40 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9951 mL | |
| 50 mM | 0.0318 mL | 0.1592 mL | 0.3184 mL | 0.7961 mL | |
| 60 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6634 mL | |
| 80 mM | 0.0199 mL | 0.0995 mL | 0.1990 mL | 0.4976 mL | |
| 100 mM | 0.0159 mL | 0.0796 mL | 0.1592 mL | 0.3980 mL |
YSK 05 Related Classifications
HY-147087 Related Classifications
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