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Cat. No.: HY-182063

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Z226407860

Z226407860 is a RING-box protein 1 (RBX1) inhibitor. Z226407860 reduces house dust mite-induced airway epithelial injury and ROS accumulation by inhibiting RBX1. Z226407860 can be used for the research of asthma.

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CAS No.: 2419496-02-7
화학식: C₂₈H₃₆N₄O₅S
분자량:540.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Z226407860 Chemical Structure

CAS No.: 2419496-02-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Z226407860 (5 μM) potently inhibits the expression of RBX1 mRNA and protein in normal HBE cells, and suppresses HDM-induced overexpression of RBX1 protein in HBE cells^[1].
Z226407860 (5 μM) alleviates HDM-induced epithelial barrier dysfunction in HBE cells by restoring the levels of Occludin and E-cadherin, and reduces the accumulation of reactive oxygen species (ROS) in cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2419496-02-7
분자량 540.67
화학식 C₂₈H₃₆N₄O₅S
SMILES

OC1=CC=C(CCC2CCN(C(CCC3=NC(C=C(S(N4CCOCC4)(=O)=O)C=C5)=C5N3C)=O)CC2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Feng L, et al. Z226407860 attenuates HDM-induced airway epithelial injury and ROS accumulation via RBX1 inhibition. Bioorg Chem. 2026;173:109646. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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