1. Anti-infection
  2. Influenza Virus
  3. Lesofavumab

Lesofavumab  (Synonyms: MHAB5553A; RG70026)

Cat. No.: HY-P99699

Lesofavumab (MHAB5553A) is a human IgG1κ anti-influenza B virus antibody.

For research use only. We do not sell to patients.

Lesofavumab Chemical Structure

Lesofavumab Chemical Structure

CAS No. : 1807960-57-1

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Lesofavumab (MHAB5553A) is a human IgG1κ anti-influenza B virus antibody[1].

IC50 & Target

Influenza B virus[1]

In Vitro

Lesofavumab (MHAB5553A) binds to a conserved epitope in the vestigial esterase domain of hemagglutinin (HA), a major immunodominant surface glycoprotein on influenza B viruses, and blocks HA-mediated membrane fusion in the endosome[1].
Lesofavumab (46B8) is able to neutralize all eleven IBV strains tested that were associated with human infections spanning >70 years, with IC50 values ranging from 0.58 to 0.95 nM[2].
Lesofavumab (46B8; 0-100 ng/mL) blocks membrane fusion and induces antibody-dependent cellular cytotoxicity (ADCC) in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lesofavumab (46B8; 15 mg/kg; i.v.; single dose) is able to protect mice against lethal challenge of the mutant influenza B virus[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/2 J mice, B/Wisconsin/1/2010, B/Brisbane/60/2008, B/Victoria/504/2000, B/Russia/1/1969 or B/Massachusetts/3/1966 infection model[2]
Dosage: 15 mg/kg
Administration: Intravenous administration, single dose, 24, 48 or 72 h post infection
Result: Treatment at 24 and 48 h post infection resulted in 100% protection, with the only exception of mice infected with B/Russia/1/1969 that showed a 60% protection when treatment commenced at 48 h. Even when given at 72 h post infection, 48B8 was highly efficacious resulting in 100% protection against the B/Brisbane/60/2008, B/Victoria/504/2000 and B/Massachusetts/3/1966 strains, 75% protection against B/Wisconsin/1/2010 and 50% protection against B/Russia/1/1969.



Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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