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  4. Linagliptin methyldimer

Linagliptin methyldimer is an impurity of Linagliptin. Linagliptin is a DPP-IV inhibitor, with IC50 of 1 nM.

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Linagliptin methyldimer Chemical Structure

Linagliptin methyldimer Chemical Structure

CAS No. : 1418133-47-7

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Linagliptin methyldimer Related Antibodies

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Description

Linagliptin methyldimer is an impurity of Linagliptin. Linagliptin is a DPP-IV inhibitor, with IC50 of 1 nM[1].

Molecular Weight

945.08

Formula

C50H56N16O4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(N(C1=C(C2=O)N(C(N3C[C@@H](CCC3)N)=N1)CC#CC)C)N2CC4=NC(CC5(N=C(NC6=C5C=CC=C6)CN7C(N(C8=C(C7=O)N(C(N9C[C@@H](CCC9)N)=N8)CC#CC)C)=O)C)=C%10C=CC=CC%10=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (132.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0581 mL 5.2906 mL 10.5811 mL
5 mM 0.2116 mL 1.0581 mL 2.1162 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0581 mL 5.2906 mL 10.5811 mL 26.4528 mL
5 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2906 mL
10 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
15 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
20 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3226 mL
25 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
30 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
40 mM 0.0265 mL 0.1323 mL 0.2645 mL 0.6613 mL
50 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5291 mL
60 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4409 mL
80 mM 0.0132 mL 0.0661 mL 0.1323 mL 0.3307 mL
100 mM 0.0106 mL 0.0529 mL 0.1058 mL 0.2645 mL
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Linagliptin methyldimer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linagliptin methyldimer1418133-47-7OthersInhibitorinhibitorinhibit

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