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Cat. No.: HY-155952

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LOC1886

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LOC1886 is a covalent inhibitor of GPX4 with slightly lower potency than RSL3 and ML162.

For research use only. We do not sell to patients.

Purity: 98.03%
CAS No.: 951948-38-2
Formula: C₁₃H₁₁N₃O₂
Molecular Weight:241.25

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

LOC1886 Chemical Structure

CAS No.: 951948-38-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

LOC1886 is a covalent inhibitor of GPX4 with slightly lower potency than RSL3 and ML162^[1].

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

Chemical Information

CAS No. 951948-38-2
Appearance Solid
Molecular Weight 241.25
Formula C₁₃H₁₁N₃O₂
Color White to off-white
SMILES

O=C(N1C=NC=C1)C2=CC3=C(N2)C=CC=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu H, et al. Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol. 2022 Dec 15;29(12):1680-1693.e9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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LOC1886

High-Throughput Bioactive Compound Library

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LOC1886 Related Classifications

HY-155952 Related Classifications