MAO-B-IN-62
MAO-B-IN-62 is a MAO-B inhibitor with an IC50 of 0.8 μM against MAO-B. MAO-B-IN-62 also acts as a PPARγ agonist with an EC50 of 14.6 μM. MAO-B-IN-62 binds to the active site of free MAO-B and activates PPARγ, both with a slow dissociation rate and sustained target-binding capacity. MAO-B-IN-62 exhibits antioxidant and anti-inflammatory activities. MAO-B-IN-62 can be used in the research of neurodegenerative diseases.
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- Formule: C24H22N4O6S4
- Masse moléculaire:590.71
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
14.6 μM
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PPARγ transactivation agonist activity in transiently transfected human HepG2 cells assessed as luciferase activity after 20 h treatment by GAL4-PPARγ transactivation assay.
PPARγ transactivation agonist activity in transiently transfected human HepG2 cells assessed as luciferase activity after 20 h treatment by GAL4-PPARγ transactivation assay.
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42527373 |
In Vitro
MAO-B-IN-62 (compound 5) exhibits direct antioxidant activity by reducing ABIP-induced DCF oxidation by 65% in in vitro assays[1].
MAO-B-IN-62 (5 μM; 30 min) significantly reduces Antimycin A-induced ROS production in LN229 glioblastoma cells and C20 microglial cells[1].
MAO-B-IN-62 (100 μM; 1 h pretreatment + 24 h LPS stimulation) reduces LPS-induced pro-inflammatory cytokine release in enriched cultures of rat astrocytes[1].
MAO-B-IN-62 (1-100 μM; 48 h or PPARγ assay duration) shows no cytotoxicity in HepG2, LN229 and C20 cell lines even at concentrations as high as 100 μM[1].
MAO-B-IN-62 is a selective, reversible, competitive inhibitor of human recombinant MAO-B, with a Ki value of 1.8 μM; it inhibits MAO activity in rat astrocyte lysates with an IC50 of 0.8 μM[1].
MAO-B-IN-62 (100 μM; 4-20 h) is a selective full PPARγ agonist with an EC50 of 14.6 μM, which exhibits persistent target binding and slow dissociation in transfected HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LN229 human glioblastoma cells, C20 human immortalized microglial cells
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Concentration:10, 20 μM
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Incubation Time:48 h
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Result:Did not affect cell viability at tested concentrations.
Chemical Information
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Masse moléculaire 590.71
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Formule C24H22N4O6S4
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SMILES
O=C(NC1=CC=C(CC(SC(N2)=O)C2=O)C=C1)CSSCC(NC3=CC=C(CC(SC(N4)=O)C4=O)C=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-62 Related Classifications
HY-187811 Related Classifications
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