2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Margatoxin

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

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Custom Peptide Synthesis

Margatoxin

Margatoxin 화학구조

CAS No. : 145808-47-5

사이즈 가격 재고 수량
100 μg 해외재고보유
500 μg 해외재고보유
1 mg 해외재고보유
5 mg   견적 받기  
10 mg   견적 받기  

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Margatoxin:

Margatoxin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Margatoxin

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2].

IC50 & Target

Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1]
In Vivo

Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

4178.95

화학식

C178H286N52O50S7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
Sequence Shortening

TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
Structure Classification
Initial Source

Centruroides margaritatus
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

용액&용해도
In Vitro: 

DMSO : ≥ 2 mg/mL (0.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.17%

SDS (393 KB)

COA (276 KB) RP-HPLC (265 KB) MS (225 KB)

Handling Instructions (2659 KB)
References
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Margatoxin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Margatoxin145808-47-5Potassium ChannelKcsAalpha-KTxscorpiontoxinKv1.3Kv1.2Kv1.139amino-acid-longpeptideCentruroidesmargaritatuschannelInhibitorinhibitorinhibit

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상품명:
Margatoxin
Cat. No.:
HY-P1280
수량:
MCE Japan Authorized Agent:

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비고

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

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