MC-VC-PABC-Aur0101
Based on 1 publication(s) in Google Scholar
MC-VC-PABC-Aur0101 is a agent-linker conjugate for ADC with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the ADC linker MC-VC-PABC.
For research use only. We do not sell to patients.
- Purity : 99.70%
- CAS No.: 1438849-92-3
- Formula: C68H100N12O14S
- Molecular Weight:1341.66
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MC-VC-PABC-Aur0101
MoreAll Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Auristatin |
In Vitro
MC-VC-PABC-Aur0101 is protease-cleavable[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1438849-92-3
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Appearance Solid
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Molecular Weight 1341.66
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Formula C68H100N12O14S
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Color White to off-white
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SMILES
O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@H]([C@@]3([H])N(CCC3)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC(C(C)(C)NC(OCC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)=O)=O)=O)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Cancer Ther
MTX-13, a Novel PTK7-Directed Antibody-Drug Conjugate with Widened Therapeutic Index Shows Sustained Tumor Regressions for a Broader Spectrum of PTK7-Positive Tumors. [Abstract]2023 Oct 2;22(10):1128-1143. PMID: 37352387
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (74.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7453 mL | 3.7267 mL | 7.4535 mL | 18.6336 mL |
| 5 mM | 0.1491 mL | 0.7453 mL | 1.4907 mL | 3.7267 mL | |
| 10 mM | 0.0745 mL | 0.3727 mL | 0.7453 mL | 1.8634 mL | |
| 15 mM | 0.0497 mL | 0.2484 mL | 0.4969 mL | 1.2422 mL | |
| 20 mM | 0.0373 mL | 0.1863 mL | 0.3727 mL | 0.9317 mL | |
| 25 mM | 0.0298 mL | 0.1491 mL | 0.2981 mL | 0.7453 mL | |
| 30 mM | 0.0248 mL | 0.1242 mL | 0.2484 mL | 0.6211 mL | |
| 40 mM | 0.0186 mL | 0.0932 mL | 0.1863 mL | 0.4658 mL | |
| 50 mM | 0.0149 mL | 0.0745 mL | 0.1491 mL | 0.3727 mL | |
| 60 mM | 0.0124 mL | 0.0621 mL | 0.1242 mL | 0.3106 mL |
MC-VC-PABC-Aur0101 Related Classifications
HY-128955 Related Classifications
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