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Cat. No.: HY-P4133

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MEK1 Derived Peptide Inhibitor 1

MEK1 Derived Peptide Inhibitor 1 is a ERK2 inhibitor that inhibits the activation of ERK2 by MEK1 in vitro, with an IC₅₀ of 30 μM, and exhibits selectivity for ERK over JNK and p38 kinases. MEK1 Derived Peptide Inhibitor 1 can be used to study ERK activation and ERK-mediated responses.

For research use only. We do not sell to patients.

CAS No.: 355367-87-2
Formula: C₆₈H₁₁₈N₁₈O₁₇S
Molecular Weight:1491.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MEK1 Derived Peptide Inhibitor 1 Chemical Structure

CAS No.: 355367-87-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All ERK Isoforms :

All MEK Isoforms :

In Vitro

MEK1 Derived Peptide Inhibitor 1 (Peptide 1) potently and selectively inhibits MEK1-mediated activation of purified ERK2 protein in vitro, with an IC₅₀ of 30 μM^[1].
MEK1 Derived Peptide Inhibitor 1 fails to inhibit ERK activation in PMA-stimulated NIH 3T3 cells at concentrations >100 μM due to the lack of cellular uptake^[1].
MEK1 Derived Peptide Inhibitor 1 fails to inhibit ERK activation in NGF-stimulated PC12 cells at concentrations >100 μM due to the lack of cellular uptake^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 355367-87-2
Molecular Weight 1491.84
Formula C₆₈H₁₁₈N₁₈O₁₇S
Sequence

Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro
Sequence Shortening

MPKKKPTPIQLNP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kelemen BR, et al. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. The Journal of biological chemistry. 2002 Mar 08;277(10):8741-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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MEK1 Derived Peptide Inhibitor 1

All ERK Isoforms

All MEK Isoforms