Mitochondrial penetrating peptide 

Mitochondrial penetrating peptide is a peptide sequence (FrFKFrFK-CONH₂) that selectively transports cargo into mitochondria. Mitochondrial penetrating peptide possesses special physicochemical properties, enabling it to selectively translocate dinuclear Ru (II) polypyridine complexes into mitochondria of living mammalian cells without the aid of solvents or membrane permeabilization treatments, thus achieving precise mitochondrial localization and enrichment of the complexes while excluding their distribution in the nucleus. Mitochondrial penetrating peptide enables dynamic monitoring of mitochondrial oxygen concentration and ROS production in living mammalian cells via changes in the luminescence lifetime of the coupled Ru (II) complex^[1].

Mitochondrial penetrating peptides can selectively target conjugated dinuclear ruthenium (II) polypyridine complexes to the mitochondria of living HeLa cells, enabling precise organelle localization, while exhibiting extremely low cytoplasmic background and no nuclear accumulation^[1].
Mitochondrial penetrating peptide enables the rapid uptake of conjugated dinuclear ruthenium (II) polypyridine complexes by live HeLa and CHO cells in a concentration- and temperature-dependent manner, and this membrane penetration process is energy-dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1174.44

C₆₀H₈₇N₁₇O₈

Phe-d{Arg}-Phe-Lys-Phe-d{Arg}-Phe-Lys-NH2

F-d{Arg}-FKF-d{Arg}-FK-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Martin A, et al. Peptide-bridged dinuclear Ru(II) complex for mitochondrial targeted monitoring of dynamic changes to oxygen concentration and ROS generation in live mammalian cells. J Am Chem Soc. 2014;136(43):15300-15309.