1. Immunology/Inflammation
  2. NO Synthase
  3. Nω-Propyl-L-arginine

Nω-Propyl-L-arginine (Synonyms: N-omega-Propyl-L-arginine)

Cat. No.: HY-102062
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Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).

For research use only. We do not sell to patients.

Nω-Propyl-L-arginine Chemical Structure

Nω-Propyl-L-arginine Chemical Structure

CAS No. : 137361-05-8

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Description

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].

In Vivo

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2].

Animal Model: Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2]
Dosage: 20 mg/kg
Administration: I.p.
Result: Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
Molecular Weight

216.28

Formula

C₉H₂₀N₄O₂

CAS No.

137361-05-8

SMILES

N=C(NCCC)NCCC[[email protected]](N)C(O)=O

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Keywords:

Nω-Propyl-L-arginineN-omega-Propyl-L-arginineNO SynthaseNitric oxide synthasesNOSlocomotoractivityeNOSstimulatoryantipsychoticpsychotomimeticInhibitorinhibitorinhibit

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