Nampt activator-1

Name: Nampt activator-1
Brand: MedChemExpress
SKU: HY-148815
Rating: 4.5 (0 reviews)

Cat. No.: HY-148815 Purity: 98.63%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Nampt activator-1 is a nicotinamide phosphoribosyltransferase (NAMPT) activator, with an EC₅₀ of 3.3~3.7 μM. Nampt activator-1 enhances the enzymatic activity of NAMPT. Nampt activator-1 can be used for research related to metabolic disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Nampt activator-1 화학구조

CAS No. : 701929-65-9

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	320 nM Compound: 10	Antiproliferative activity against human A2780 cells assessed as reduction in cell growth measured for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell growth measured for 72 hrs by MTT assay	[PMID: 38580317]

In Vitro

Nampt activator-1 (Compound 1) moderately enhances NAMPT activity, with a maximum activation effect E_max of up to 75%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

299.32

화학식

C₁₆H₁₇N₃O₃

CAS No.

701929-65-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC)C1=CC=C(NC(NCC2=CC=NC=C2)=O)C=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 250 mg/mL (835.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3409 mL	16.7045 mL	33.4091 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 98.63%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) HNMR (253 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Akiu M, et al. Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition. Bioorg Med Chem Lett. 2021;43:128048.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3409 mL	16.7045 mL	33.4091 mL	83.5226 mL
	5 mM	0.6682 mL	3.3409 mL	6.6818 mL	16.7045 mL
	10 mM	0.3341 mL	1.6705 mL	3.3409 mL	8.3523 mL
	15 mM	0.2227 mL	1.1136 mL	2.2273 mL	5.5682 mL
	20 mM	0.1670 mL	0.8352 mL	1.6705 mL	4.1761 mL
	25 mM	0.1336 mL	0.6682 mL	1.3364 mL	3.3409 mL
	30 mM	0.1114 mL	0.5568 mL	1.1136 mL	2.7841 mL
	40 mM	0.0835 mL	0.4176 mL	0.8352 mL	2.0881 mL
	50 mM	0.0668 mL	0.3341 mL	0.6682 mL	1.6705 mL
	60 mM	0.0557 mL	0.2784 mL	0.5568 mL	1.3920 mL
	80 mM	0.0418 mL	0.2088 mL	0.4176 mL	1.0440 mL
	100 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8352 mL