2. Metabolic Enzyme/Protease
  3. NAMPT E1/E2/E3 Enzyme
  4. NAMPT activator-9

NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC50 of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD+ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy.

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NAMPT activator-9

NAMPT activator-9 Chemical Structure

CAS No. : 931366-46-0

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NAMPT activator-9 Related Antibodies

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Description

NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC50 of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD+ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy[1].

In Vitro

NAMPT activator-9 (60 min) is a potent allosteric activator of hNAMPT, with an EC50 of 3.366 μM[1].
NAMPT activator-9 (0.741-20 μM; 24 h) significantly increases the intracellular NAD+ level and NAD+/NADH ratio in fully differentiated C2C12 myotubes; after treatment with 2.222 μM for 24 h, the NAD+ level increases by approximately 2-fold[1].
NAMPT activator-9 (2.222-20 μM; 24 h) protects fully differentiated C2C12 myotubes against Dexamethasone (HY-14648)-induced atrophy by reducing the expression of atrophy markers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAMPT activator-9 Related Antibodies

Cell Viability Assay[1]

Cell Line: Fully differentiated C2C12 myotubes
Concentration: 0.247-4860 μM
Incubation Time: 24 h
Result: Showed no obvious toxicity in C2C12 myotubes up to 180 μM, with an IC50 value of 1.98 mM.

Western Blot Analysis[1]

Cell Line: Fully differentiated C2C12 myotubes (dexamethasone-induced atrophy model)
Concentration: 2.222-20 μM (co-incubated with 10 μM dexamethasone)
Incubation Time: 24 h
Result: Nearly completely abolished Dexamethasone-induced upregulation of Atrogin-1 and MuRF1 expression.
Reversed dexamethasone-induced reduction of MyHC expression, with significant recovery at all tested concentrations.
Molecular Weight

305.33

Formula

C17H15N5O
CAS No.
SMILES

O=C(N1CC2=C(C=CC=C2)CC1)C3=CC=C(C4=NNN=N4)C=C3
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Purity & Documentation
References
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NAMPT activator-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAMPT activator-9931366-46-0NAMPT activator9NAMPT activator 9NAMPTE1/E2/E3 EnzymeNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSER-275ASP-219muscle atrophyC2C12 myotubesNAD+MuRF1Atrogin-1myosin heavy chainVAL-242Inhibitorinhibitorinhibit

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