ARHGAP5 - Rho GTPase activating protein 5 Gene

Also Known as GFI2; p190-B; RhoGAP5; p190BRhoGAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 394

About ARHGAP5

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:32,075,880-32,159,728 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 87 phenotypes. Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues.

Summary

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate Cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP5 Products (2)

mRNA Protein Name
NM_001030055.2 NP_001025226.1 rho GTPase-activating protein 5 isoform a
NM_001173.3 NP_001164.2 rho GTPase-activating protein 5 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
1689011 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23622247 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP5 Protein Structure

Ras

Ras: Ras family (155 - 246)

FF

FF: FF domain (485 - 545)

RhoGAP

RhoGAP: RhoGAP domain (1275 - 1423)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1502 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 5

  • growth factor independent 2

ARHGAP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
ARHGAP5 Q13017 Rnd3 Mus musculus P61588
Anti Tag CoIP
23622247
Cross: Cross-species interaction Intra: Intraspecies interaction

ARHGAP5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83074 RhoGAP Antibody (YA2819) WB, IHC-P, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00939 ARHGAP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARHGAP5 VGNC VGNC:70008
Rattus norvegicus ARHGAP5 RGD RGD:1308507
Bos taurus ARHGAP5 VGNC VGNC:26098
Canis familiaris ARHGAP5 VGNC VGNC:38067
Felis catus ARHGAP5 VGNC VGNC:68119
Mus musculus ARHGAP5 MGD MGI:1332637
Others ARHGAP5 NCBI