MYO1C - myosin IC Gene

Also Known as NMI; MMIb; myr2; MyoIC; MMI-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4641

About MYO1C

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,464,186-1,492,686 (from NCBI)

This gene has 20 transcripts (splice variants), 205 orthologues, 43 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues.

Summary

This gene encodes a member of the unconventional Myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene Myosin IE has been referred to as Myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

MYO1C Products (4)

mRNA Protein Name
NM_001080779.2 NP_001074248.1 unconventional myosin-Ic isoform a
NM_001080950.2 NP_001074419.1 unconventional myosin-Ic isoform b
NM_001363855.1 NP_001350784.1 unconventional myosin-Ic isoform d
NM_033375.5 NP_203693.3 unconventional myosin-Ic isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21402783 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21402783 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
21402783 GOA
involved in positive regulation of transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
16603771 GOA
involved in protein targeting to membrane IDA
IDA: Inferred from direct assay
21402783 GOA
involved in protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
23262137 GOA
involved in regulation of bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
21402783 GOA
involved in vascular endothelial growth factor signaling pathway IMP
IMP: Inferred from mutant phenotype
23262137 GOA
Cellular Component GO Annotation Evidence References Source
part of B-WICH complex IDA
IDA: Inferred from direct assay
16603771 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21402783 GOA
located in membrane IDA
IDA: Inferred from direct assay
21402783 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
23262137 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23262137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO1C Protein Structure

Myosin_head

Myosin_head: Myosin head (motor domain) (56 - 718)

IQ

IQ: IQ calmodulin-binding motif (737 - 754)

IQ

IQ: IQ calmodulin-binding motif (759 - 776)

Myosin_TH1

Myosin_TH1: Unconventional myosin tail, actin- and lipid-binding (873 - 1058)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1063 a.a.
Protein Preferred Names Protein Names

unconventional myosin-Ic

  • myosin-I beta

Related Diseases

Diseases Alias
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

  • Autosomal Dominant Isolated Neurosensory Deafness Type Dfna

  • Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna

  • Autosomal Dominant Isolated Sensorineural Deafness Type Dfna

  • Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna

  • Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna

  • Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna

  • Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Granulomatous Amebic Encephalitis

  • Granulomatous Amoebic Encephalitis

  • Acanthamoeba Encephalitis

  • Acanthamoeba Granulomatous Encephalitis

  • Granulomatous Amebic Encephalitis Due To Acanthamoeba
Chromosome 17p13.3, Centromeric, Duplication Syndrome

  • Chromosome 17p13.3 Duplication Syndrome

  • 17p13.3 Duplication Syndrome

  • 17p13.3 Microduplication Syndrome

  • Trisomy 17p13.3

  • Chromosome 17p13.3 Centromeric Duplication Syndrome

  • Dup(17)(P13.3)
Primary Amebic Meningoencephalitis

  • Pam

  • Naegleria Fowleri Infection

  • Meningoencephalitis Caused By Naegleria Fowleri

  • Primary Amoebic Meningoencephalitis
Myopathy, Centronuclear, 1

  • Autosomal Dominant Centronuclear Myopathy

  • CNM1

  • Centronuclear Myopathy 1

  • Ad-Cnm

  • Myopathy, Centronuclear, Autosomal Dominant

  • Myotubular Myopathy, Autosomal Dominant

  • Centronuclear Myopathy, Autosomal, Modifier Of

  • Autosomal Dominant Myotubular Myopathy

  • Dnm2-Related Centronuclear Myopathy

  • Centronuclear Myopathy Autosomal Dominant

  • Myopathies, Structural, Congenital

  • Myopathy, Centronuclear, Type 1
Miller-Dieker Lissencephaly Syndrome

  • Miller-Dieker Syndrome

  • Mds

  • MDLS

  • Miller Dieker Syndrome

  • Classical Lissencephaly Syndrome

  • Lissencephaly Due To 17p13.3 Deletion

  • Monosomy 17p13.3

  • Telomeric Deletion 17p

  • Classical Lissencephaly
Amebiasis

  • Amoebiasis

  • Entamoebiasis

  • Chronic Intestinal Amebiasis

  • Amoebiasis, Unspecified

  • Amebic Colitis

  • Amoebic Enteritis

  • Infection Due To Entamoeba Histolytica

  • Amoebic Infection

  • Disease Due To Endamoebidae

  • Amoebiasis Nos
Usher Syndrome, Type I

  • USH1

  • Usher Syndrome Type 1

  • Us1

  • Usher Syndrome, Type 1b

  • Usher Syndrome Type 1e

  • Retinitis Pigmentosa And Congenital Deafness

  • Usher Syndrome, Type Ie

  • USH1E

  • Usher Syndrome, Type 1e

  • Usher Syndrome, Type 1a

  • Usher Syndrome, Type Ib

  • Usher Syndrome Type 1b

  • Usher Syndrome Type Ie

  • Usher Syndrome Type I

  • Usher 1

  • Usher Syndrome, Type 1

  • Ush1a

  • Usher Syndrome, Type I, French Variety

  • Usher Syndrome, Type Ia

  • Usher Syndrome 1b

  • USH1B

  • Usher'S Syndrome Type 1b

  • Usher Syndrome Type Ib

  • Ushib
Usher Syndrome

  • Deafness-Retinitis Pigmentosa Syndrome

  • Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

  • Graefe-Usher Syndrome

  • Hallgren Syndrome

  • Usher'S Syndrome

  • Retinitis Pigmentosa-Deafness Syndrome

  • Retinitis Pigmentosa-Hearing Loss Syndrome

  • Ush

  • Usher Syndromes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08939 MYO1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08941 MYO1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21659 Myo1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28177 Myo1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYO1C VGNC VGNC:68390
Macaca mulatta MYO1C VGNC VGNC:75112
Bos taurus MYO1C VGNC VGNC:31818
Mus musculus MYO1C MGD MGI:106612
Rattus norvegicus MYO1C RGD RGD:620443
Canis familiaris MYO1C VGNC VGNC:43562
Others MYO1C NCBI