NLRP3-IN-43
NLRP3-IN-43 (compound II-8) is a poteny inhibitor of NLRP3 inflammasome activation that binds to the LRR domain, and disrupts NLRP3-NEK7 interaction.
For research use only. We do not sell to patients.
- CAS No.: 2769903-01-5
- Formula: C25H31N5OS
- Molecular Weight:449.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
>100 μM
Compound: Cpd II-8
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Cytotoxicity against human THP-1 cells assessed as cellular proliferation inhibition measured after 48 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as cellular proliferation inhibition measured after 48 hrs by MTT assay
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[PMID: 38888047] |
Chemical Information
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CAS No. 2769903-01-5
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Molecular Weight 449.61
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Formula C25H31N5OS
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SMILES
O=C(C1=CC=C(CN2C3=CN=CC=C3N=C2SCC4CCCCC4)C=C1)N5CCNCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-43 Related Classifications
HY-163756 Related Classifications
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