PD-L1/CD-73-IN-1
PD-L1/CD-73-IN-1 (compound CC-5) is PD-L1/CD73 inhibitor with IC50 values of 6 nM and 0.773 μM to PD-L1 and CD73, respectively. PD-L1/CD-73-IN-1 inhibits tumor cell growth in vivo and in vitro.
For research use only. We do not sell to patients.
- CAS No.: 3048634-84-7
- Formula: C47H45ClN8O5
- Molecular Weight:837.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B16-F10 | IC50 |
>10 μM
Compound: CC-5
|
Antiproliferative activity against mouse B16-F10 cells
Antiproliferative activity against mouse B16-F10 cells
|
[PMID: 38748913] |
| CT26 | IC50 |
>10 μM
Compound: CC-5
|
Antiproliferative activity against mouse CT26 cells
Antiproliferative activity against mouse CT26 cells
|
[PMID: 38748913] |
| Jurkat | EC50 |
1.92 μM
Compound: CC-5
|
Inhibition of protein-protein interaction of PD-1 (unknown origin) overexpressed in human Jurkat cells overexpressing NFAT/PD-L1 (unknown origin) overexpressed in CHO cells overexpressing TCR ligand preincubated with CHO cells for 0.5 hrs followed by Jurk
Inhibition of protein-protein interaction of PD-1 (unknown origin) overexpressed in human Jurkat cells overexpressing NFAT/PD-L1 (unknown origin) overexpressed in CHO cells overexpressing TCR ligand preincubated with CHO cells for 0.5 hrs followed by Jurk
|
[PMID: 38748913] |
Chemical Information
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CAS No. 3048634-84-7
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Molecular Weight 837.36
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Formula C47H45ClN8O5
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SMILES
N#CC1=CC=CC(COC2=CC(OCC3=C(C(C4=CC=CC=C4)=CC=C3)C)=C(C=C2CN5C(CCCC5)C(N6CCN(CC6)C7=NN=C(C=C7)C8=CNC(NC8=O)=O)=O)Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)