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Cat. No.: HY-179602

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PROTAC 11β-HSD1 Degrader 1

PROTAC 11β-HSD1 Degrader 1 is a highly efficient PROTAC targeting 11β-HSD1 (Hydroxysteroid 11-beta dehydrogenase 1). PROTAC 11β-HSD1 Degrader 1 demonstrates ubiquitin-proteasome-dependent degradation of 11β-HSD1. PROTAC 11β-HSD1 Degrader 1 can be used for the study of type 2 diabetes mellitus (T2DM).
(Pink: 11β-HSD1 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker (HY-42490)).

For research use only. We do not sell to patients.

Formula: C₅₉H₇₉N₁₁O₉S
Molecular Weight:1118.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PROTAC 11β-HSD1 Degrader 1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC 11β-HSD1 Degrader 1 is a highly efficient PROTAC targeting 11β-HSD1 (Hydroxysteroid 11-beta dehydrogenase 1). PROTAC 11β-HSD1 Degrader 1 demonstrates ubiquitin-proteasome-dependent degradation of 11β-HSD1. PROTAC 11β-HSD1 Degrader 1 can be used for the study of type 2 diabetes mellitus (T2DM)^[1]. (Pink: 11β-HSD1 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker (HY-42490)).

All PROTACs Isoforms :

In Vitro

PROTAC 11β-HSD1 Degrader 1 (Compound 25) (0.12-10 μM, 48 h) can effectively degrade 11β-HSD1 in the MV-4-11 cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MV-4-11 cell
Concentration:

0.12 μM, 0.37 μM, 1.1 μM, 3 μM, 5 μM, 10 μM
Incubation Time:

48 h
Result:

Dose-dependent degradation of 11β-HSD1 in the MV-4-11 cell line.

In Vivo

PROTAC 11β-HSD1 Degrader 1 (Compound 25) (50 mg/kg, i.p., once every two days for 2 weeks) can effectively improve glucose homeostasis in mice with type 2 diabetes induced by a high-fat diet^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old male C57BL/6J wild-type mice were fed a high-fat diet for eight weeks^[1].
Dosage:

50 mg/kg
Administration:

I.p., once every two days for 2 weeks
Result:

Significantly improved glucose tolerance in mice.
Enhanced glucose-stimulated insulin secretion.
Showed a decreasing trend in body weight and random blood glucose levels.

Chemical Information

Molecular Weight 1118.39
Formula C₅₉H₇₉N₁₁O₉S
SMILES

O=C(C1=C(C(C)(C)C)N(C2=CC=C(C(NCC3=CN(CCOCCOCCOCCC(N[C@H](C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)C(C)(C)C)=O)N=N3)=O)C=C2)N=C1)NC78CC9CC(C8)CC(C9)C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang L, et al. Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention [preprint]. bioRxiv [Internet]. 2025 Nov 09

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PROTAC 11β-HSD1 Degrader 1

All PROTACs Isoforms