2. PROTAC MAPK/ERK Pathway Immunology/Inflammation
  3. PROTACs MAP4K Interleukin Related IFNAR
  4. PROTAC HPK1 Degrader-7

PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research.
(Pink: MAP4K and Ligands for Target Protein for PROTAC and HPK1 ligand (HY-179731); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-179730); Black: linker).

For research use only. We do not sell to patients.

PROTAC HPK1 Degrader-7

PROTAC HPK1 Degrader-7 Chemical Structure

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PROTAC HPK1 Degrader-7 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research[1]. (Pink: MAP4K and Ligands for Target Protein for PROTAC and HPK1 ligand (HY-179731); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-179730); Black: linker).

IC50 & Target[1]

HPK1

3.07 nM (DC50)

Molecular Weight

844.98

Formula

C46H53FN10O5
SMILES

O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(C4=CN=C5OCCNC5=C4C)C=C3)=O)=C1C)NCCN6CCN(CC7CCN(C8=CC=C(N(C(N9)=O)CCC9=O)C=C8F)CC7)CC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC HPK1 Degrader-7 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HPK1 Degrader-7PROTACsMAP4KInterleukin RelatedIFNARMAPK Kinase Kinase KinaseILInterferon-α/β receptorInterferon-alpha/beta receptorHPK1SLP-76 phosphorylationhuman primary T cellsInhibitorinhibitorinhibit

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