PROTAC HPK1 Degrader-7
PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research.
(Pink: HPK1 ligand (HY-179731); Blue: Cereblon ligand (HY-179730); Black: linker).
For research use only. We do not sell to patients.
- Formula: C46H53FN10O5
- Molecular Weight:844.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HPK1 3.07 nM (DC50) |
Chemical Information
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Molecular Weight 844.98
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Formula C46H53FN10O5
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SMILES
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(C4=CN=C5OCCNC5=C4C)C=C3)=O)=C1C)NCCN6CCN(CC7CCN(C8=CC=C(N(C(N9)=O)CCC9=O)C=C8F)CC7)CC6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HPK1 Degrader-7 Related Classifications
HY-179727 Related Classifications
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