Protein Kinase C (19-35) Peptide
Based on 1 Customer Validation
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 309247-48-1
- Formula: C89H153N33O22
- Molecular Weight:2037.40
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Amino acids equivalent to residues 19-36 and 19-29 of PKC-β can bound to phospholipid vesicles[2].
Atypical zeta protein kinase C in the signaling pathway leading to chemoattractant-triggered actin assembly, integrin-dependent adhesion of blood leukocytes to vascular endothelium[3].
Synthetic myristoylated peptides with Protein Kinase C (19-35) Peptide, the endogenous zeta protein kinase C pseudosubstrate region, block agonist-induced adhesion to fibrinogen, chemotaxis and F-actin accumulation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 309247-48-1
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Appearance Solid
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Molecular Weight 2037.40
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Formula C89H153N33O22
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Color White to off-white
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Sequence Shortening
RFARKGALRQKNVHEVK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (49.08 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Steiner J, et al. The effect of acute ethanol (EtOH) exposure on protein kinase C (PKC) activity in anterior pituitary. Alcohol. 1997 May-Jun;14(3):209-11. [Content Brief]
[2]. Mosior M, et al. Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes. Biophys J. 1991 Jul;60(1):149-59. [Content Brief]
[3]. Laudanna C, et al. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem. 1998 Nov 13;273(46):30306-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4908 mL | 2.4541 mL | 4.9082 mL | 12.2705 mL |
| 5 mM | 0.0982 mL | 0.4908 mL | 0.9816 mL | 2.4541 mL | |
| 10 mM | 0.0491 mL | 0.2454 mL | 0.4908 mL | 1.2271 mL | |
| 15 mM | 0.0327 mL | 0.1636 mL | 0.3272 mL | 0.8180 mL | |
| 20 mM | 0.0245 mL | 0.1227 mL | 0.2454 mL | 0.6135 mL | |
| 25 mM | 0.0196 mL | 0.0982 mL | 0.1963 mL | 0.4908 mL | |
| 30 mM | 0.0164 mL | 0.0818 mL | 0.1636 mL | 0.4090 mL | |
| 40 mM | 0.0123 mL | 0.0614 mL | 0.1227 mL | 0.3068 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Protein Kinase C (19-35) Peptide Related Classifications
HY-P3892 Related Classifications
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