Two new constituents of Isodon excisus and their evaluation in an apoptosis inhibition assay
- J Nat Prod. 2001 May;64(5):659-60. doi: 10.1021/np000604g.
Affiliations
- 1. Korea Research Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115, Yusong, Taejon 305-600, Korea.
PMID: 11374970
DOI: 10.1021/np000604g
Abstract
Investigation of the whole plant of Isodon excisus resulted in the isolation of two new Apoptosis inhibitors (1 and 2). Compounds 1 and 2 inhibited etoposide-induced Apoptosis in U937 cells with IC50 values of 10.2 and 52.4 microg/mL, respectively. The structures of 1 and 2 were determined by spectral data interpretation.