Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes

  • J Pineal Res. 2001 Sep;31(2):183-5. doi: 10.1034/j.1600-079x.2001.310214.x.
E Maronde  1 ,  H W Korf ,  P Niemann ,  H G Genieser
Affiliations
  • 1. Dr. Senckenbergische Anatomie, Anatomisches Institut II, J.W. Goethe Universität, Frankfurt, Germany. [email protected]
PMID: 11555176 DOI: 10.1034/j.1600-079x.2001.310214.x
Abstract

A modified analog of cyclic adenosine 3',5'-monophosphate (cAMP), Sp-adenosine-3',5'-monophosphorothioate, designed to be highly membrane-permeable and resistant towards phosphodiesterases was found to induce the phosphorylation of the cAMP-regulated transcription factor cyclic AMP-responsive element binding protein in cultured rat pinealocytes more efficiently than previously described cAMP analogs.

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