Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative

  • Bioorg Med Chem Lett. 2002 Jan 21;12(2):265-6. doi: 10.1016/s0960-894x(01)00728-4.
David Egron  1 ,  Christian Périgaud ,  Gilles Gosselin ,  Anne-Marie Aubertin ,  Hiroyuki Gatanaga ,  Hiroaki Mitsuya ,  Jiri Zemlicka ,  Jean-Louis Imbach
Affiliations
  • 1. UMR CNRS 5625, Université Montpellier II, cc 008, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
PMID: 11755368 DOI: 10.1016/s0960-894x(01)00728-4
Abstract

The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4'-hydroxy-1',2'-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.

Products