Control of IRF-3 activation by phosphorylation

  • J Interferon Cytokine Res. 2002 Jan;22(1):73-6. doi: 10.1089/107999002753452674.
Mitsutoshi Yoneyama  1 ,  Wakako Suhara ,  Takashi Fujita
Affiliations
  • 1. Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan.
PMID: 11846977 DOI: 10.1089/107999002753452674
Abstract

Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by posttranslational modifications. We review current knowledge of the mechanism of IRF-3 activation: signalling triggered by infections including viruses and bacteria, phosphorylation of IRF-3 on certain serine residues, homodimer formation, and active holocomplex formation with coactivator CBP/p300.