Croblongifolin, a new anticancer clerodane from Croton oblongifolius

  • Planta Med. 2002 Mar;68(3):274-7. doi: 10.1055/s-2002-23138.
Sophon Roengsumran ,  Kusalin Musikul ,  Amorn Petsom ,  Tirayut Vilaivan ,  Polkit Sangvanich ,  Surachai Pornpakakul ,  Songchan Puthong ,  Chaiyo Chaichantipyuth ,  Nongnuj Jaiboon ,  Narongsak Chaichit
PMID: 11914970 DOI: 10.1055/s-2002-23138
Abstract

A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.

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