Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile
- Phytomedicine. 1999 Nov;6(5):341-5. doi: 10.1016/S0944-7113(99)80056-7.
Affiliations
- 1. Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson 85721, USA.
PMID: 11962541
DOI: 10.1016/S0944-7113(99)80056-7
Abstract
Screening of Plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several Pentacyclic Triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.
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